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Antiepileptic Drugs Lyrica Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8

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Antiepileptic Drugs Lyrica Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8

Antiepileptic Drugs Lyrica Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8
Antiepileptic Drugs Lyrica Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8 Antiepileptic Drugs Lyrica Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8

Large Image :  Antiepileptic Drugs Lyrica Pharmaceutical Raw Materials Pregabalin CAS 148553-50-8 Get Best Price

Product Details:
Place of Origin: China(WhatApp:+8618971485175)
Brand Name: VKD
Certification: ISO9001,SGS,GMP
Model Number: 148553-50-8
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Price: contact Allen whatsapp:+8618971485175
Packaging Details: Aluminum foil bag + carton
Delivery Time: 24hour
Payment Terms: Western Union, MoneyGram, T/T,bitcoins
Supply Ability: 100kg/month
Detailed Product Description
Type: Anesthetic Agents Purity: 99%
Cas No.: 148553-50-8 Grade Standard: Medicine Grade
Appearance: White Crystalline Powder Shelf Life: 2 Years
High Light:

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Whatsapp:+8618971485175

Wickr : allenraws0437

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Detailed Product Description
Product Name: Pregabalin CAS: 148553-50-8
MF: C8H17NO2 MW: 159.23
EINECS: 200-659-6 Appearance: Off-White Solid
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Product Name: Pregabalin​

Product details:

 

Product Name Pregabalin
Alias 3-(aminomethyl)-5-methyl-hexanoic acid; Pregablin; (3S)-3-(aminomethyl)-5-methyl-hexanoic acid; (R-)-3-isobutyl GABA; 3-isobutyl GABA; CI 1008; CI-1008; 3-(aminomethyl)-5-methyl-(3S)-Hexanoic acid; 3-(aminomethyl)-5-methyl-(S)-Lyrica; PD 144723; PD-144723; Pregabalin [USAN]; TOS-BB-0910; Pregabalin intermediate; (3R)-3-(aminomethyl)-5-methylhexanoic acid; (S)-Pregabalin; (S)(+)-3-Aminomethyl-5-methyl-hecanoic acid
CAS 148553-50-8
EINECS 253-874-2
Molecular Formula C8H17NO2
Molecular Weight 159.23
Assay 99.8%
Density 0.997g/cm3
Boiling Point 274°C at 760 mmHg
Flash point 119.5°C
Vapour Pressure 0.00153mmHg at 25°C
InChI InChI=1/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
Appearance White or white crystalline powder
Usage New antiepileptic drugs. Used in the treatment of peripheral neuropathy, or partial seizures

 

 

Description:

 

Pregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23. Pregabalin is a white to off-white, crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is 1.35.

 

LYRICA (pregabalin) Capsules are administered orally and are supplied as imprinted hard-shell capsules containing 25, 50, 75, 100, 150, 200, 225, and 300 mg of pregabalin, along with lactose monohydrate, cornstarch, and talc as inactive ingredients. The capsule shells contain gelatin and titanium dioxide. In addition, the orange capsule shells contain red iron oxide and the white capsule shells contain sodium lauryl sulfate and colloidal silicon dioxide. Colloidal silicon dioxide is a manufacturing aid that may or may not be present in the capsule shells. The imprinting ink contains shellac, black iron oxide, propylene glycol, and potassium hydroxide. LYRICA (pregabalin) oral solution, 20 mg/mL, is administered orally and is supplied as a clear, colorless solution contained in a 16 fluid ounce white HDPE bottle with. Polyethylene-lined closure. The oral solution contains 20 mg/mL of pregabalin, along with methylparaben, propylparaben, monobasic sodium phosphate anhydrous, dibasic sodium phosphate anhydrous, sucralose, artificial strawberry #11545 and purified water as inactive ingredients.

 

 

Application:

 

Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. S-Enantiomer of Pregabalin. A GABA analogue used as an anticonvulsant. Anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia.

Pregabalin is used to relieve neuropathic pain (pain from damaged nerves) that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes or in the area of your rash if you have had shingles (a painful rash that occurs after infection with herpes zoster). It is also used to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). Pregabalin is used with other medications to treat certain types of seizures in people with epilepsy. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body. Pregabalin works by reducing the abnormal electrical activity in the brain. It is taken alongside other medicines for epilepsy. Pregabalin can also be helpful in treating the symptoms of generalised anxiety disorder (GAD), particularly if other medicines which are more often prescribed for people with this condition are not suitable. GAD is along-term condition where anxiety is amajor symptom.


Pregabalin, also known as -isobutyl--Aminobutyric acid (-isobutyl-GABA) and sold under the trade name Lyrica among others, is amedication used to in the treatment of epilepsy, neuropathic pain, fibromyalgia and generalized anxiety disorder. Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults. Pregabalin is astructural analogue of the neurotransmitter GABA, consequently it belongs to the -Aminobutyric acid analogue class of antiepileptic drugs. Its aion channel modulator that has analgesic, anticonvulsant, sedative, and anxiolytic properties. Pregabalin is apotent gabapentinoid and close analogue of GABOB (-hydroxy-GABA), baclofen (-(4-chlorophenyl)-GABA), and phenibut(-phenyl-GABA).

Pregabalin belongs to a group of medicines known as anti-epileptic medicines, although it is prescribed for the treatment of several different conditions. You may have been prescribed it for the treatment of partial seizures, which is a type of epilepsy. A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. With a partial seizure, the burst of electrical activity stays in one part of the brain. Therefore, you tend to have localised or 'focal' symptoms. Pregabalin is also prescribed to treat certain types of long-lasting pain caused by damage to nerves. This type of pain, called neuropathic pain, can be caused by a number of different conditions, including diabetes (where it is called diabetic neuropathy) and shingles(where it is called postherpetic neuralgia).

 

99% Treatment Antiepileptic Drugs Lyrica Pharmaceutical Raw Materials Powder Pregabalin CAS 148553-50-8

 

 

COA:

 

ITEMS STANDARDS RESULTS
Appearance A white to off white powder White powder
Identification A. Meets the requirement Complies
B. IR: similar to Reference Substance Complies
Loss on drying ≤0.5% 0.21%
Specific Rotation +10.0°~+13.0° +10.8°
Related Substances Any single impurity ≤0.1%
Total impurity ≤0.8%
0.05%
0.10%
Purity By HPLC R-isomer ≤0.15% 0.10
Residue on ignition ≤0.1% 0.05%
Residual solvents Isopropyl alcohol ≤5000ppm
Ethyl Acetate ≤5000ppm
150ppm
250ppm
Heavy metals ≤10ppm Complies
Chlorides ≤0.05% Complies
Assay 98%~102.0% 99.8%
Conclusion Analyse according to Factory Standard , Conform

 

 

Function:

 

Seizures
Pregabalin is useful when added to other treatments, when those other treatments are not controling partial epilepsy. Its use alone is less effective than some other seizure medications. It is unclear how it compares to gabapentin for this use.

 

Neuropathic pain
The European Federation of Neurological Societies recommends pregabalin as a first line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain. A minority obtain substantial benefit, and a larger number obtain moderate benefit. Other first line agents, including gabapentinand tricyclic antidepressants, are given equal weight as first line agents, and unlike pregabalin, are available as less expensive generics. Pregabalin is not recommended for certain other types of neuropathic pain such as pain that of trigeminal neuralgia or HIV infection and its use in cancer-associated neuropathic pain is controversial.There is no evidence for its use in the prevention of migraines and gabapentin has been found not to be useful. It has been examined for the prevention of post-surgical chronic pain, but its utility for this purpose is controversial.

 

Anxiety disorders
Therapeutic effects of pregabalin appear after 1 week of use and is similar in effectiveness to venlafaxine, but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychic and somatic anxiety symptoms.Long-term trials have shown continued effectiveness without the development of tolerance, and, in addition, , it has a beneficial effect on sleep and sleep architecture, characterized by the enhancement of slow-wave sleep. and produces less severe cognitive and psychomotor impairment;

 

 

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