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|Molecular Formula:||C8H9NO2||Molecular Weight:||151.16|
|EINECS Number:||203-157-5||Melting Point:||168-172 °C (lit.)|
|Boiling Point:||273.17°C (rough Estimate)||Storage Conditions:||Store At RT|
pharma raw materials,
pharmaceutical grade raw materials
Pharmaceutical Raw Materials Paracetamol Powder Relieve pain CAS.103-90-2
CAS No.: 103-90-2
Molecular formula: C8H9NO2
Molecular weight: 151.16
EINECS number: 203-157-5
Melting point 168-172 °C (lit.)
Boiling point 273.17°C (rough estimate)
Storage conditions Store at RT
Uses Mainly used for fever caused by cold, headache and relieve mild to moderate pain, such as joint pain, muscle pain, neuralgia, migraine, dysmenorrhea, cancer pain and postoperative analgesia. It can also be used in patients who are allergic to aspirin, intolerant or unsuitable for aspirin: patients with chickenpox, hemophilia and other bleeding disorders (including those who have anticoagulant therapy), as well as patients with mild peptic ulcer and gastritis.
Paracetamol, also known as acetaminophen, is traded under the trade names of Baishenning, Bilitong, Tylenol, and acetaminophen. It is truly a panacea for our time. From joint sprains to headaches, brain heat, from gum swelling to neuropathic pain, you can see it anywhere, anytime.
Its history of development dates back to the ancient Middle Ages, when the only antipyretic drug was a substance found in the bark of willow (a class of salicylic acid that later developed into Hot-selling aspirin) and a substance found in the bark of the cinchona tree. Cinchona bark is also the main raw material used to make anti-malarial drugs quinine and quinidine, and it also has antipyretic effect. It was not until the mid-to-late 19th century that techniques for the extraction of salicin and salicylic acid were developed.
In 1955, Johnson & Johnson marketed paracetamol in the United States under the trade name Tylenol. In 1956, 500 mg of paracetamol produced by GlaxoSmithKline (GSK) was marketed in the UK under the trade name Panadol. In 1963, paracetamol was included in the British Pharmacopoeia and became popular due to its minor side effects and interaction with other drugs. At this point, the paralyzed "Bright Road" really opened.
By inhibiting cyclooxygenase, it selectively inhibits the synthesis of prostaglandins in the hypothalamic body temperature regulation, leading to peripheral vasodilatation and sweating to achieve antipyretic effect. Its antipyretic effect is similar to that of aspirin; by inhibiting the synthesis of prostaglandins And release, improve pain threshold and play an analgesic effect, belonging to peripheral analgesics, weaker than aspirin, effective only for mild to moderate pain
(1) Oral doses for adults are taken orally. Once 0.3-0.6g, once every 4 hours, or 4 times a day; the amount of one day should not exceed 2g, the course of treatment for fever is generally no more than 3 days, for analgesia should not exceed 10 days.
(2) Oral doses for children. According to the weight of 10-15mg/kg each time or 1.5g/m2 per body surface area, once every 4-6 hours; children under 12 years old do not exceed 5 times every 24 hours, the course of treatment does not exceed 5 days.
1. Toxic side effects of the liver: If a large amount of paracetamol is taken for a long time, it may cause necrosis of liver cells, because paracetamol has certain damage to the liver. Therefore, if you take a certain amount for a long time, the effectiveness of detoxification of the liver will be far lower. In severe cases, fulminant hepatic failure can occur and cause death.
2. Toxic side effects of the kidney: If excessive consumption of paracetamol also causes kidney damage, necrosis of kidney cells.
3, the toxic side effects of the blood system: As the saying goes, it is a drug three-point poison. Therefore, if the toxin produced by long-term use of paracetamol is accumulated in a certain amount, it will cause damage to our blood system.
4, the toxic side effects of the nervous system: for children still said to try not to take paracetamol, because it will cause damage to the central nervous system. Causes neurological dysfunction and slows down development.
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