Pharmaceutical Grade Raw Materials Phenacetin Antipyretic Analgesics

Local Anesthetic Powder Phenacetin Antipyretic analgesics CAS. 62-44-2

 
 
phenacetin(Fenacetina Fenacetine)
CAS No: 62-44-2
Molecular formula: C10H13NO2
Molecular weight: 179.22
EINECS number: 200-533-0
Melting point 133-136 °C (lit.)
Boiling point 132 °C / 4mmHg
Storage conditions 2-8 ° C
Use Paracetamol is used as a raw material for organic synthesis and as a pharmaceutical intermediate.
Use raw materials for scientific research
Uses Substrate for CYP1A2 and CYP2D6.
Use antipyretic analgesics for the treatment of fever, headache, neuralgia, etc.
 
The origin of Phenacetin
Phenacetin is a pain-relieving and fever-reducing drug that was introduced in 1887 and widely used by the US Food and Drug Administration in 1983 for its use in the United States. Its use has declined because of its side effects, including increased risk of certain cancers and kidney damage.
Phenacetin is also known as acetophenetidins. Glossy leaflets or scaly crystals, odorless or taste, stable in air, soluble in water, slightly soluble in boiling water, slightly soluble in ether, soluble in ethanol, chloroform. It is formed by etherification, reduction and acetylation of p-chloronitrobenzene.
 
 
 
Phenacetin Dosage:
 
Analgesic mixtures containing phenacetin were previously marketed as tablets or capsules containing between 150 and 300 mg phenacetin. Common combinations were: 150 mg phenacetin, 230 mg aspirin, and 15 or 30 mg caffeine; or 150 mg phenacetin, 230 mg aspirin, 30 mg caffeine, and 8, 15, 30, or 60 mg codeine phosphate. Phenacetin alone was also available in 250 and 300 mg doses as tablets, and up to 500 mg doses as powder. The usual dose was 300 mg 4-6 times per day, and the daily dose was not to exceed 2 g.
 
 
 
Some over-the-counter painkiller manufacturers replaced phenacetin with paracetamol, a similar drug that has not been shown to be a carcinogen. Paracetamol is also known as acetaminophen. Studies have shown that acetaminophen also can cause damage to the kidneys, but its side effects are not as serious as those of phenacetin.
 
Phenacetin is still available as a prescription medication in some countries, particularly in Europe. It has drawn attention for its use by gangs in the United Kingdom to dilute cocaine. The two drugs have a close physical resemblance.