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Human Growth Hormone Peptide Delta Sleep Inducing Peptide(DSIP)
The Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group, which separated it from rabbit cerebral blood that induced sleep. Because of its apparent ability to induce slow wave sleep in rabbits, it is primarily thought to involve sleep regulation.
Delta Sleep Inducing Peptide, abbreviated DSIP, is a neuropeptide that induces fusiform and δEEG activity and reduces motor activity when infused into the midbrain of the recipient rabbit.
DSIP has pressure protection, anti-epileptic effects, and immunomodulatory effects. DSIP has been shown to have significant genetic protection.
DSIP has been shown to induce sleep. Second, it may be used as an analgesic to treat chronic pain, sometimes as an adjunctive therapy. DSIP has achieved positive results in inducing slow wave EEG (sleep). It has been shown to help treat narcolepsy and restore disturbed sleep patterns to normal sleep rhythms.
Delta Sleep Inducing Peptide (DSIP) is a nonapeptide with a unique amino acid sequence (Table 1) isolated from rabbit cerebral venous blood that is subjected to low frequency ('hypnosis') electrical stimulation of the thalamic thalamic nucleus.
Delta Sleep Inducing Peptide (DSIP) is a neuropeptide found in the hypothalamus, pituitary and adrenal glands. Its isolation allows for extensive research and several possible major and peripheral effects of the peptide have been found.
Over the next three decades, extensive research in many laboratories has demonstrated that DSIP, or some structurally closely related peptides (s), exist in free form and in combination in some brain structures, primarily the hypothalamus. And limbic systems, as well as pituitary and different peripheral organs, tissues and body fluids, where it colocalizes with several peptide and non-peptide media.
DSIP research trial
In a wide range of psychophysiological observations and double-blind crossover design measurements, six normal volunteers (four males and two females) were subjected to DSIP (= synthetic delta sleep-inducing peptide) for the first study in humans.
DSIP was applied as a slow intravenous infusion at a dose of 25 nmol / kg in the morning. Subjects immediately reported sleep stress, with a 59% increase in sleep time (median total sleep time) within 130 minutes of treatment compared with placebo.
The delayed effect on subsequent nighttime sleep is a reduction in sleep onset time, a decrease in the percentage of the first phase, and a better sleep efficiency. Despite this, complex behavior and EEG analysis showed that classical pharmacological methods have no sedative effects.
The results show that human DSIP is also effective by maintaining natural sleep function. The compound was well tolerated and no psychological, physiological or biochemical side effects were observed.
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