Product Details:
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Chemical Name: | Tetracaina Hcl | Alias: | Tetracaine Hcl |
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MF: | C15H24N2O2 | MW: | 264.36 |
Function: | Anesthetic | Appearance: | White Crystal Powder |
High Light: | tetracaine hcl powder,benzocaine lidocaine tetracaine 15 5 5 |
Tetracaine Hydrochloride Powder 99% Pure Safe Clearance USP/BP Standard
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Basic Information
CAS number | 136-47-0 | Molecular formula | C15H25ClN2O2 |
Molecular weight | 300.82 | EINECS number | 205-248-5 |
Melting point | 149°C | Density | 1.1279 (rough estimate) |
What is Tetracaina hcl?
Tetracaine is a widely used local anesthetic
The strength is stronger than lidocaine, benzocaine, procaine.
Tetracaine is the T in TAC, a mixture of 5 to 12 per cent tetracaine, 0.05 per cent adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
Tetracaine hcl is a long acting ester topical anesthetic. The action of the peripheral nerves is similar to that of other local anesthetics. It can change the membrane permeability to sodium ions and prevent sodium ions from flowing in, thus slowing down the action potential until the action potential stops, resulting in the loss of nerve excitation and conduction, unable to transmit information. The drug is more soluble than procaine, has a strong permeability, and binds to nerve tissue quickly and firmly. The anesthetic effect is 5 to 10 times that of procaine, and the action time is 8 times that of procaine, but the toxicity is 10 times greater.
Pharmacokinetics this drug has high fat solubility and can penetrate the mucous membrane. During the 60 - to 90-minute period of local anesthesia, the procedure lasts one to three minutes. The subarachnoid block is effective for 3 to 5 minutes and lasts for 2 to 3 hours. When epinephrine was added, the duration increased to 4 to 6 hours. It is mainly hydrolyzed by plasma pseudocholinesterase and its metabolites are para-aminobenzoic acid and dimethylaminoethanol. It is excreted mainly in the form of metabolites by the kidney and a small amount in the form of urine.
Common Use of tetracaina hcl
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
A systematic review investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first attempt cannulations.
Characteristics of tetracaina, lidocaina, benzocaina, procaina.
And which anesthesia effect is good?
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Product description
Tetracaine hydrochloride is a highly effective local anesthetic that reversibly blocks nerve function. It is clinically used for infiltration anesthesia, nerve block anesthesia, epidural anesthesia, etc. Compared with procaine, its local anesthetic effect is significantly better in Chemicalbook. Has been widely used in clinical. Studies on existing synthetic routes have found that the synthesis of the intermediate p-butylaminobenzoic acid is a key step in the synthesis of tetracaine hydrochloride, and the raw materials have been unstable at this step.
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