HPLC Hexarelin Muscle Building Peptides 98 Percent Purity CAS 140703-51-1

98% Purity (HPLC) Body Building Peptide Hexarelin (2mg/Vial)

Desctiprion:

Product Name: Hexarelin

Synonyms: Examorelin

CAS: 140703-51-1

MF: C47H58N12O6

MW: 887.04

Purity (HPLC): 98.0%

Appearance: White powder

Single Impurity (HPLC): 0.5%max

Amino Acid Composition: ±10% of theoretical

Peptide Content (N%): ≥80.0%

Water Content(Karl Fischer): ≤8.0%

Acetate Content(HPIC): ≤10.0%

Description:

Hexarelin is a six-amino acid peptide. Studies have shown that hexarelin is actually more

effective and longer lasting than growth hormone releasing hormone (GHRH). It is also known that

GHRP-6 has a synergistic effect with GHRH, causing a far greater release than either of these

substances alone. By combining GHRP-6 with Hexarelin, a more potent GH releasing peptide

combination is created than ever heard of. The potential clinical usefulness of these GH releasing

hexapeptides is also reinforced by observations that long-term administration produces

elevations in circulating IGF-1 concentrations. Long term treatment with GHRP-6 similarly has

been shown to elevate serum IGF-1 as well as IGF-binding protein-3 concentrations and promote

linear growth.

Hexarelin comes in a freeze dried powder just like the other GHRP peptides and storage should

be done in a cool dry place until reconstituted and placed in a refrigerator. Bacteriostatic water is

used to reconstitute the powder and an insulin syringe is the preferred method for administering

subcutaneous injections of hexarelin. Users will notice 200mcgs is the saturation dose for

hexarelin and over a few weeks of use total desensitization may begin to take place. Also, the

occasional flare up of the pituitary has been noted when dosing far beyond saturation doses.

Desensitization can be cleared easily by taking a break from hexerlin usage for a few days to a

few weeks. This GHRP is the strongest, and because of the desensitization factor, I believe the

optimal way to use this peptide would be to blend it at low doses with other GHRP's like GHRP2,

GHRP6 or iPamorelin.

Application:

Hexarelin is an appetite-regulating factor secreted from peripheral organs that is involved in

regulation of energy homoeostasis via binding to the receptor resulting in the secretion of by the

pituitary gland.The pathway activated by binding of Hexarelin to the secretagogue receptor,

GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric

oxide synthase, and AMPK cascades in different cellular systems.
 

One of the important features of GHSR1a displays constitutive activity possessing basal activity

in the absence of an agonist, resulting in a high degree of receptor internalization as well as of

signaling activity.Inverse agonists for the Hexarelin receptor could be particularly interesting for

the treatment of obesity.This activity seems to provide a tonic signal required for the development

of normal height, probably through an effect on the GH axis

Benefits:

Interestingly, the most amazing finding with hexarelin was its ability to act on cardiac receptors

separate from the GH releasing properties. The peptide can directly aid in cardio protective left

ventricular pressure issues, as well as, help healing scar tissue on the heart. Studies on lean and

obese lab rats concluded that while lean rats were able to take advantage of the GH plasma

increase better than the obese rats (the healthier the rat the more hexarelin effectively produced

and utilized GH), obese rats did not see the same advantage. Separate from the studies that

monitored GH, both lean and obese rats both received all of the cardio protective properties of

hexarelin.

The functionality:

Hexarelin (Hexarelin Acetate) is chemically designed as L-Histidyl-2-methyl-D-tryptophyl-L-alanyl-

L-tryptophyl-D-phenylalanyl-L-lysinamide. Hexarelin (Hexarelin Acetate) is a potent GHRP-6

analog, whose structure (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2) creates a greater stability

than GHRP-6 due to a substituted (2 Me)Trp. Hexarelin has a half-life of about 70 min, longer than

that of GHRP-6. Replacement of the naturally occurring L-amino acids for the D-configuration

results in these longer half-lives.

Secretion:

Hexarelin has shown that it is highly stimulated at 30 minutes after being induced by rapid and

sustained GH secretion. The pituitary gland produces GH in the brain, in children this hormone

helps them to grow and in adults it helps to maintain muscle and burn fat. In one sixteen-week

study, it has been shown that GH levels return to normal after stopping use after four weeks.