Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a 'fake' Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there.
Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially 'tricks' the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.
Toremifene is also agonistic to Estrogen receptors in other tissues in the body (within the liver in particular). This means that whileToremifene will act as an anti-estrogen in breast tissue and the hypothalamus, it will act as an Estrogen within the liver. This can have beneficial impacts especially during an anabolic steroid cycle, such as improving and shifting cholesterol levels into a more favorable range.
In the fight against breast cancer, standard Toremifene Citrate doses will normally be 60mg per day. The total duration of use is unpredictable and will be based on patient need. It's not uncommon for treatment to last a year or two and then AI's to be added if needed. Once the cancer is in remission, compounds like Toremifene Citrate are commonly used to support the improved state.
For the anabolic steroid user combating gynecomastia, standard Toremifene Citrate doses will fall in the 30-60mg per day range and will work very well for most men. If this is not enough protection, while you could try increasing the dose your best bet would be to move to AI use. You will find Toremifene Citrate works very well in combating gynecomastia due to the use of any testosterone, Dianabol and Anadrol. You will also find Toremifene Citrate works well with Equipoise and Deca Durabolin. However, as Deca Durabolin is also a progestin, men who are very sensitive to that hormone may need an AI. The same can be said of the Trenbolone hormone.
Trenbolone does not aromatize, but it is a progestin. Further, the use of an aromatizing steroid with a compound like Trenbolone can increase the risk of gynecomastia in some men. While many will not need gynecomastia protection due to progestins and will get by with SERM's to combat aromatase, some sensitive men will need an AI. Regardless, if Toremifene Citrate works for you it will cover the entire breadth of the cycle from start to finish.
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1. It is clinically proven. In a number of important measurements of a drug's effectiveness in treating metastatic ER+ breast cancer in postmenopausal women, Fareston worked just as well as tamoxifen1-4
2. May provide the continued benefits of endocrine therapy. Fareston may offer you the continued benefits of endocrine therapy if you cannot tolerate or are otherwise unable to take other endocrine therapies1-6
3. Fareston may be an effective alternative for patients who have stopped taking other endocrine therapies because of joint pain1-4,6
4. Is available and accessible. Fareston is widely available on commercial and Medicare Part D formularies and is covered by most commercial and Medicare insurance plans.
For bodybuilding purposes, a dose of 40-60mgs per day seems to be a good starting place. If the user is attempting to fight existing gynecomastia (bitch tits), they may choose to double the dose and add an aromatase inhibitor like Aromasin by using it. For PCT, many will kick-start with 100-120mgs daily and then lower to 40-60mgs daily for 4-6 weeks.
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||Tamoxifen Citrate (Nolvadex)
||Clomiphene Citrate (Clomid)
||Toremifene Citrate (Fareston)