Synonyms: 1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4'-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE
CAS: 62-44-2
MF: C10H13NO2
MW: 179.22
EINECS: 200-533-0
Product Categories: Other APIs;Organics;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 62-44-2.mol
Phenacetin Structure

Phenacetin Chemical Properties
Melting point 133-136 °C(lit.)
Boiling point 132 °C / 4mmHg
Fp 2℃
storage temp. 2-8°C
form powder
color White
Water Solubility 0.076 g/100 mL
Sensitive Hygroscopic
Merck 14,7204
BRN 1869238
Stability: Stable. Incompatible with strong oxidizing agents, strong acids.
InChIKey CPJSUEIXXCENMM-UHFFFAOYSA-N
CAS DataBase Reference 62-44-2(CAS DataBase Reference)
NIST Chemistry Reference Acetamide, N-(4-ethoxyphenyl)-(62-44-2)
EPA Substance Registry System Acetamide, N-(4-ethoxyphenyl)-(62-44-2)

Safety Information
Hazard Codes T,F
Risk Statements 45-22-20/21/22-36-11
Safety Statements 53-45-36/37-26-16
RIDADR UN 3077 9 / PGIII
WGK Germany 3
RTECS AM4375000
TSCA Yes
Hazardous Substances Data 62-44-2(Hazardous Substances Data)
MSDS Information
Provider Language
4-Acetophenetidine English
ACROS English
SigmaAldrich English
ALFA English

Application

It is also called acetophenetidin. Having glossy leaflets or scales-like crystals that have no odor or

taste. Melting point 133-136 °C. Stable in air, soluble in water, slightly soluble in boiling water,

slightly soluble in ether, soluble in ethanol, chloroform. It is formed through the

etherification,reduction and Acetylation reaction of pchloronitrobenzene. As chloroacetanilide

antipyretic and analgesic agent. Suitable for fever,headache, neuralgia and other drugs as a

compound agent.

Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting

as aspirin, low toxicity. Research shows that: This product and its metabolites acetaminophen

have the antipyretic effect. Because the enzyme inhibitor make phenacetin not be converted into

paracetamol, still showed obvious antipyretic effect,thus the antipyretic effect after the product

line not converrt to paracetamol.The mild phenacetin analgesic effect usually lasts 3 to 4 hours;

and synergistic effect, of alicylic acid coadministrationmake the analgesic effect enhancement.

The main clinical is for small animal antipyretic analgesic. This product is also a component of the

APC tablet.

Phenacetin is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887

until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects,

which include increased risk of certain cancers and kidney damage. It is metabolized into

paracetamol, which replaced it in some over-the-counter medications following the ban

on phenacetin.

COA