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Product Details:
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| High Light: | Lidocaine Local Anesthetic Powder,C14H22N2O Local Anesthetic Powder,CAS 137-58-6 |
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| Appearance: | White Powder | Other Name: | Lidocaine |
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| Shipping Method: | EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC | MF: | C14H22N2O |
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local anesthesia drugs,pain killer powder |
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CAS:137-58-6
MF:C14H22N2O
MW:234.34
EINECS:205-302-8
Synonyms:2-(Diethylamino)-2',6'-acetoxylidide;2-(diethylamino)-2’,6’-acetoxylidide ;2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid ;2',6'-Acetoxylidide, 2-(diethylamino)-;6’-acetoxylidide,2-(diethylamino)-2 ;Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-;Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)- ;a-Diethylamino-2,6-acetoxylidide
Melting point:66-69°C
Boiling point:bp4 180-182°; bp2 159-160°
Flash point:9℃
storage temp. Store at RT
solubility ethanol: 4 mg/mL
form powder
color White to slightly yellow
Water Solubility practically insoluble
Merck 14,5482
Stability:Stable. Incompatible with strong oxidizing agents.
Symbol(GHS)
Abstract
Lidocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or used as a local anesthetic for minor surgery. It replaces procaine,being widely used in plastic and cosmetic operation in local infiltration anesthesia, the sodium channel inhibition of the nerve cell membrane to block nerve excitability and conduction.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system
The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy.Therefore,lidocaine is suitable for infiltration,block,and surface anesthesia.Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias;lidocaine,though,has the advantage of a rapid onset of action.
Epinephrine vasoconstricts arteries,reducing bleeding and also delays the resorption of lidocaine,almost doubling the duration of anaesthesia.For surface anesthesia,several available formulations can be used e.g. for endoscopies,before intubations,etc.Buffering the pH of lidocaine makes local freezing less painful.Lidocaine drops can be used on the eyes for short ophthalmic procedures.
Relative insensitivity to lidocaine is genetic.In hypokalemic sensory overstimulation,relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.In dental anesthesia,a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves.Some people with Ehlers-Danlos syndrome are insensitive to lidocaine.
| Items | Claims | Results |
| Appearance | White crystalline powder | Pass |
| Content Wt. | 99.00%-101.00% | 99.72% |
| Identification | Chloridate | Positive |
| Test A | Positive | |
| Melting point | 74-79ºC | 75.8-77.3ºC |
| Appearance of solution | Clear and colourless | Pass |
| Water | 5.5-7.0% | 5.8% |
| Acidity PH | 4.0-5.5 | 5.3 |
| Sulphated ash | 0.10% max | 0.06% |
| Heavy metals | 5ppm max | Pass |
| 2, 6-Dimethylaniline | 100ppm max | Pass |
| Sulfate | Meet the requirement | Pass |
| Conclusion | Qualified | |
Lidocaine, also known as xylocaine and lignocaine, is a medication used to numb tissue in a specific area and to treat ventricular tachycardia.It can also be used for nerve blocks. Lidocaine mixed with a small amount of epinephrine is available to allow larger doses to be used as numbing and to make it last longer.When used as an injectable it typically begins working within four minutes and lasts for half an hour to three hours. Lidocaine may also be applied directly to the skin for numbing.
Medical uses
Local numbing agent
The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action. Epinephrine (adrenaline) vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local numbing less painful.[10] Lidocaine drops can be used on the eyes for short ophthalmic procedures.
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