Selank is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular
Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-
Lys-Pro-Arg-Pro-Gly-Pro. It is a synthetic analogue of a human tetrapeptide tuftsin.
Selank is a synthetic analogue of the immunomodulatory peptide tuftsin; as such, it mimics many
of its effects. It has been shown to modulate the expression of Interleukin-6 (IL-6) and affect the
balance of T helper cell cytokines. It has been shown to influence the concentration of monoamine
neurotransmitters and induce metabolism of serotonin. There is evidence that it may also
modulate the expression of brain-derived neurotropic factor (BDNF) in rats.
Selank, as well as a related peptide drug, semax, have been found to inhibit enzymes involved in
the degradation of enkephalins and other endogenous regulatory peptides, and this action may
be involved in their effects.
While Selank is classified as a nootropic-anxiolytic type drug, it uses extend beyond the relief of
anxiety and improved cognitive functioning alone. A few areas in which Selank may find itself
useful are: Stress reduction, the alleviation of depression, reversal of anhedonia, improvement in
mood in emotionally stable individuals, and cessation of insomnia. Of course, with Selank being
a nootropic-anxiolytic, it may also prove useful for the treatment of different forms of anxiety, such
as G. A. D (generalized anxiety disorder), S. A. D (social anxiety disorder), Panic Disorder, as
well as non-diagnosed bouts of anxiety. As a nootropic, Selank can help enhance mental
sharpness, reduce mental fatigue, improve the ability to focus, improve cognitive functioning while
in a sleep deficit, and enhance memory.
These effects are provided without the negative side effects typically associated , such as
physical dependence, psychological addiction, and decreased motor ability. In fact, Selank is
largely devoid of side effects, with the large majority of researchers claiming that it is a "side
effect free" compound. This makes Selank more suitable for long-term use.
Selank is a synthetic derivative of the human body's naturally produced tetrapeptide Tuftsin. It is a
hexapeptide whith a wide range of uses. It was first sinthesized in the late 1990's by the Institute
of Molecular Genetics of the Russian Academy of Science. Selank is used as an anxiolytic in the
therapy of anxiety and phobic disorders, including generalized anxiety. Its action is similar to that
of mild benzodiazepins but without the sedative effects. As a selective anxiolytic with a nootropic
component, Selank can be used as treatment of depression, fear and general anxiety. It also
reduces phsychic tension. This neuropeptide has passed all phases of clinical trials and is now
being prepared for registration and mass production.
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