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PT-141, also known as bremelanotide is a melanocortin (a group of pituitary peptide hormones). More specifically bremelanotide (PT-141) is a cyclic hepta-peptide lactam analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that activates the melanocortin receptors MC3-R and MC4-R in the central nervous system. It is a metabolite of Melanotan II that lacks the function of the C-terminal amide.
In the beginning, PT-141 was actually being researched as a potential for sunless tanning. In actuality, two other peptides were formed prior to the PT 141 peptide for that exact purpose, those two being Melanotan I and II. While Melanotan II went on to be the tanning agent that was being sought after, it also had a different ability. It was able to aid in sexual dysfunction and thus Bremelanotide was created.
Whether you know it as PT 141 or by its other names Bremelanotide or Vyleesi, once you experience its ability to increase sexual function you won’t want to use anything else. Unlike many other compounds on the market, like Cialis or Viagra, it is a peptide. For those of you that don’t know, peptides are created naturally within the body and therefore their synthetic variations tend to play nice with fewer side effects. In terms of this particular PT 141 peptide, it is a circular sequence of seven amino acids with something referred to as an amide group as part of the sequence.
It is a non-selective agonist of melanocortin receptors, more specifically receptors MC1 through MC5. The only receptor not affected by PT-141 is the MC2 receptor. What does this mean for your sex life? While the other receptors handle things like skin pigmentation (MC1) or homeostasis (MC3), MC4 is in charge of your sexual behaviors.
The peptide can be used by men and women both. Women that use Apoxar PT-141 note an increase in arousal and indicate an acute desire to have sex. Most manifest the effects of usage 2 hours after the injection, the peak activity is observed after 4 hours. Men note that taking the peptide allows them to feel more energetic and young, increases arousal and the level of sexual interest.
The drug is of a synthetic origin; it affects the central nervous functions that control the manifestation of sexual desire. The action of the peptide is based on it causing an erection and its further strengthening. The drug was created on the basis of Melanotan 2, which is used as a drug to enhance tanning of the skin. In the initial studies, Metanotan 2 caused a darkening of skin, but during testing it produced an adverse reaction in the form of pronounced sexual arousal and spontaneous erection in 9 out of 10 male test subjects.
As a result of studying the PT-141 peptide, it was determined that the drug is suitable for eliminating problems with sexual function or treating erectile dysfunction in men and also for women who suffer from sexual disorders and a lack of arousal. Using PT-141 allows for achieving a number of positive effects:
increased sex drive;
stimulated and strengthened penile erection;
normalized sexual vigor, increased libido;
strengthened skin tan.
ADMINISTRATION AND DOSAGE:
The effect of the drug develops over 2 hours after administration, the peak effect is observed at the 3rd-4th hour. The total duration of action is 8-10 hours. The peptide is available for purchase in vials containing lyophilized powder. It’s recommended to store Bremelanotide in the dry state at 0-8 degrees Celsius. The shelf life of the drug is 2 years. The diluted powder must be stored in a refrigerator, but in this case the shelf life is reduced to 1-3 months.
It’s recommended to dissolve the peptide using saline, in which case the resulting preparation can be kept in the freezer for about one month. Given its features of usage, it’s best to absorb the PT-141 peptide into a syringe immediately after dilution at a single dose, and then freeze. Before use, unfreeze only one syringe and do not subject it to repeated freezing. To prevent discomfort during administration, it is recommended to keep the vial in the room for some time after removing it from the refrigerator. When the drug reaches room temperature, water is added into the vial along the side for dilution (bactericidal water or saline). Mix the powder with water by rotating the vial without shaking it.
Often, injections of the peptide are carried out using insulin syringes. The injections are done subcutaneously (in much rarer cases, intramuscularly, using a five-cube syringe with a 40 mm needle). It’s not recommended to use the intranasal spray due to the likelihood of adverse reactions. The optimal single dose of the drug is at 0.5-1.5 mg of the active agent (a single vial of the peptide often contains 10 mg of powder, which is enough for 7-20 injections). The duration of the cycle depends on the goals of users.
PT-141 can be safely considered to be a valid, certified aphrodisiac. It is often used in combination with Levitra, Cialis, Viagra and other drugs used to treat disturbed sexual function. Such combinations work great even among the elderly users, but the peptide also shows high effectiveness during a solo cycle.
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