Product Details:
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Product Name: | Anastrozole | Purity: | 99% |
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Apperance: | White Powder | Usage: | Muscle Building |
High Light: | Anastrozole anti estrogen steroid,Arimidex anti estrogen steroid,Anastrozole Male Enhancement Powder |
Bodybuilding Steroid Anastrozole Effective Arimidex White Crystal Powder for Male Enhancement
Quick details:
Arimidex (Anastrozole) anti-estrogen steroid Boldenone powder
Product name: Arimidex
Synonym: arimidex Anastrozole Arimidex High quality Anastrozole Arimidex Anastrozole Arimidex tablets Anastrozole 1MG HPLC Injectable Anti Estrogen Steroids Arimidex Medicine No Side Effects/High Purity Anastrozole Arimidex
CAS No.: 120511-73-1
Molecular Formula: C17H19N5
Molecular Weight: 293.37
Assay: 99%
Appearance: White to white crystalline powder
Description:
Arimidex is the aromatase inhibitor of choice. Arimidex’s mechanism of action – blocking conversion of aromatizable steroids to estrogen – is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid) or (Nolvadex), which block estrogen receptors in some tissues, and activate estrogen receptors in others.
Anastrozole is also called Arimidex, it can be referred to as an aromatase inhibitor that helps prevent the production of estrogen in women. Research shows that the hormone estrogen is responsible for the creation of breast cancer tumors in women. Arimidex is the drug administered to intercept the aromatase enzyme. , which is a substance that helps body tissues to produce estrogen. Arimidex is a popular drug in the fight against breast cancer. It is, in general, a hormonal treatment that can prevent the recurrence of breast cancer.
Arimidex is known to reduce estrogen excessively in some patients. That is why blood or saliva tests are recommended after one week of use to determine if the dose is appropriate. Arimidex tends to work differently than traditional anti-estrogens. Anti- estrogens such as Clomid or Nolvadex tend to intercept estrogen in certain tissues while activating them in others. Meanwhile, Arimidex directly intercepts the aromatase enzyme. When a patient has been recommended to use Arimidex, Clomid is used together with unnecessary. Do this may have some benefits.
Application:
Arimidex is highly suitable for solving either problem. With correctly chosen dosing, free estradiol level can be brought fairly accurately to a desired range. When not using steroids, for most men I recommend about 20-29 pg/mL for best effect on mood, performance, libido, and long term health and to provide excellent benefit to natural production. During a cycle, levels can be allowed to rise a little higher, because high androgen levels act towards countering adverse actions of estradiol. Sometimes levels are deliberately made higher, as being a little “wet†can improve lifting performance. Still, I recommend that even during a strong cycle, estradiol level be kept to no more than about 40 pg/mL.This will usually require an aromatase inhibitor such as Arimidex, if dosing of aromatizable steroids is high.
Three azole aromatase inhibitors are potent selective, it can inhibit the cytochrome P-450 dependent aromatase thereby blocking the biosynthesis of estrogen, but estrogen is the main factor that stimulates the growth of breast cancer cells.
The treatment of breast cancer, especially for those with adjuvant hormone therapy after menopause after recurrence of women with advanced breast cancer.
Anastrozole Uses:
Arimidex is an anti estrogen hormone developed for the treatment of breast cancer. This drug is one of the third generation selective aromatase inhibitors. It works by blocking aromatase, thereby reducing the production of estrogen in the body.
When men take these drugs to reduce femininity in steroid therapy, aromatase inhibitors may increase the risk of cardiovascular disease, because aromatase inhibitors reduce the beneficial effects of estrogen and the quality of cholesterol. Studies have shown that the development of benign HDL cholesterol levels is greatly inhibited when aromatase steroids such as testosterone heptaneate are taken with aromatase inhibitors.
Because tamoxifen, an estrogen receptor agonist / antagonist, usually does not have the same anti estrogen (malignant) effect on cholesterol levels, it is still more popular than aromatase inhibitors in maintaining estrogen levels for male fitness shapers and athletes who are concerned about cardiovascular health.
COA:
Description | White crystalline powder | Complies |
Identification | IR | Conform with standard IR |
HPLC | Conform with standard HPLC | |
Reactive | Conform | |
Solubility | Freely soluble in methanol,acetone,ethanol and tetrahydrofuran. And very soluble in acetonitrile. | Complies |
Total Impurity | max.0.5% | 0.18% |
Total Unspecified Impurity | max. 0.2% | 0.08% |
Individual unspecified impurlty | max. 0.1% | 0.05% |
Related compound B | max. 0.2% | 0.07% |
Related compound C | max. 0.2% | 0.04% |
Related compound D | max. 0.1% | 0.05% |
Related compound E | max. 0.1% | 0.06% |
Limit of cyclohexane | max. 0.08% | ND |
Limit of ethylacetate | max. 0.1% | 0.07% |
Melting point | 81.0~84.0℃ | 82.5~83.2℃ |
Water | max. 0.3% | 0.21% |
Residue on ignition | max. 0.1% | 0.07% |
Heavy Metals | max.0.001% | Complies |
Assay(HPLC) | 98.0%~102.0% | 99.8% |
Storage | Cool and dry | |
Conclusion | It complies to USP32 . |
Recommended Dose:
1. Usage in men:
Anastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism. It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer. Some athletes and body builders use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogen--gynecomastia, emotional lability and water retention. Study data suggests dosages of 0.5 mg to 1 mg a day reduce serum estradiol approx. 50% in men, which differs in postmenopausal women.
2. Usage in children:
Anastrozole may be used off-label in children with precocious puberty, or children with pubertal gynecomastia.Following the onset of puberty, the epiphyseal plate begins to close due to an increased amount of estrogen production escaping local metabolism and spreading to the circulatory system. It is shown to help slow this process, and increase adult height prediction in adolescent males treated with protein-based peptide hormones for the treatment of growth hormone deficiency.
Anti Estrogen Steroids Effects:
When a man uses anabolic androgenic steroids (AAS), certain compounds will aromatize into estrogen. The main culprits that will do this are all testosterone esters, such as: cypionate, enanthate,dianabol, deca durabolin, and less so Boldenone (EQ). If estrogen isn't inhibited by using an AI (aromatase inhibitor), then high-estrogen side effects can occur. The most well-known side effect isgynecomastia or what is known commonly as 'gyno', 'bitch tits' or 'man breasts'. A man may notice a lump forming within his breast(s) - or under the nipple area; if not treated quickly, this can require serious surgery to remove. The lesser known but very serious side effects are caused by water retention, which can give a bloated or 'full' look.
Extra water weight to your body or face (commonly called “moon face for its round or full look) can ruin a nice physique by making a person look fat. Internally, carrying around extra water weight will strain the body’s lipids across the board. A person can expect a rise in blood pressure, heart strain, and loss in energy. Also, high estrogen can affect libido.
On the other hand, if you are too aggressive in inhibiting estrogen, by using compounds that are harsher than Arimidex, this can cause your estrogen to drop too low. As a result, you can expect erectile disfunction (ED), loss of energy, depression and low libido.
Anastrozole VS Letrozole:
Aromatase inhibition is the gold standard for the treatment of early and advanced breast cancer in postmenopausal women suffering from estrogen receptor positive disease. Currently established group of anti-aromatase compounds composed of reversible aromatase inhibitors (anastrozole and letrozole) and on the other hand, irreversible aromatase inactivator exemestane .Although exemestane is the only aromatase inactivator widely used at this stage, doctors very often have to choose between either anastrozole or letrozole in general practice. These third-generation aromatase inhibitors, Letrozole and Anastrozole, have recently demonstrated superior efficacy compared to tamoxifen as first-line therapy for early breast cancer to improve disease-free survival.
However, although anastrozole and letrozole belong to the same pharmacological class of agents (triazoles), a growing body of evidence suggests that these aromatase inhibitors are not equipotent when given at clinically established doses. Preclinical and clinical evidence indicate different pharmacologic profiles. Therefore, this review The focus is on the differences between non-steroidal aromatase inhibitors that allow doctors to choose between these compounds based on scientific evidence. Although we are waiting for the important results of an ongoing head-to-head comparison in patients with cancer in the early breast at high risk of relapse, clinicians must make choices today.
On the basis of the available evidence summarized here and until the FACE data become available, letrozole appears to be the best choice for the majority of breast cancer patients whenever a nonsteroidal aromatase inhibitor must be selected in a clinical setting.
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